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  1. Guideline: your weight in kg, plus 50 = total dosage in milligrams for the session. (1.5 mg/kg with a 120 mg max may be more optimal, but the weight + 50 is a good rule of thumb). If you’re more cautious or want something a little less intense, perhaps weight in kg + 35-40.
  2. If finger dipping powder: ideally switch to weighed doses, but if not that, use “crush, dab, wait.”
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Ecstasy and molly promote a feeling of well-being, happiness and friendliness. These drugs enhance the user’s sense of sight, sound, smell and touch. Ecstasy and molly are common at dance clubs and raves, allowing the user to take advantage of their heightened sensations. The effects of Ecstasy use include:

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Like most drugs, ecstasy and molly interfere with the brain’s pleasure center and natural levels of dopamine.

The high from Ecstasy generally lasts between 3 and 5 hours. Depending on a number of factors including body weight, gender, amount taken, and method of administration, Ecstacy’s effects can last up to 8 hours.

Although the “high” from the drugs usually only lasts a few hours, the crash can last for days.

Because ecstasy is illegal, any use of it is considered abuse. Some versions of ecstasy and molly do not contain any MDMA at all and the person buying them is none the wiser. Sometimes MDMA is replaced with PMA (paramethoxyamphetamine). PMA may create similar feelings to MDMA, but the onset is longer. It has a much lower lethal dose, so when users try to take more to achieve the feeling they get from MDMA, overdose is a serious possibility.

Overdosing on ecstasy means taking more than the recreational dose. Ecstasy overdose can cause seizures, foaming at the mouth and a spike in body temperature. These can cause heatstroke or aggravate an underlying heart condition, both of which can prove to be fatal.

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Commonly abused as a “party drug,” ecstasy is popular among college students, especially at raves and concerts. Studies suggest approximately 1 out of every 10 college students have experimented with the drug, and the rates of polydrug abuse are far higher among ecstasy users than other groups of drug users.

One study found that 98 percent of college students who had used ecstasy had also used marijuana. Ecstasy abusers were far more likely (anywhere from 3 times to about 30 times) to abuse inhalants, LSD, cocaine and heroin.

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Methamphetamine (Meth) is a powerfully addictive stimulant that dramatically affects the central nervous system.

The drug is made easily in clandestine laboratories with relatively inexpensive over-the-counter ingredients. These factors combine to make methamphetamine a drug with high potential for widespread abuse.

Methamphetamine is commonly known as “speed,” “meth,” and “chalk.” In its smoked form it is often referred to as “ice,” “crystal,” “crank,” and “glass.”

Meth is a white, odorless, bitter-tasting crystalline powder that easily dissolves in water or alcohol. The drug was developed early in this century from its parent drug, amphetamine, and was used originally in nasal decongestants and bronchial inhalers. Methamphetamine’s chemical structure is similar to that of amphetamine, but it has more pronounced effects on the central nervous system. Like amphetamine, it causes increased activity, decreased appetite, and a general sense of well-being. The effects of methamphetamine can last 6 to 8 hours. After the initial “rush,” there is typically a state of high agitation that in some individuals can lead to violent behavior.

Methamphetamine is a Schedule II stimulant, which means it has a high potential for abuse and is available only through a prescription that cannot be refilled. There are a few accepted medical reasons for its use, such as the treatment of narcolepsy, attention deficit disorder, and – for short-term use – obesity; but these medical uses are limited.

Meth use is rising

Drug abuse treatment admissions reported by the CEWG in December 1996 showed that methamphetamine remained the leading drug of abuse among treatment clients in the San Diego area and was second only to marijuana in Hawaii. Stimulants, including methamphetamine, accounted for smaller percentages of treatment admissions in other states and metropolitan areas of the West (e.g., 5 percent in Los Angeles and Seattle and 4 percent in Texas and San Francisco). By comparison, stimulants were the primary drugs of abuse in less than one percent of treatment admissions in most Eastern and Midwestern metropolitan areas, except in Minneapolis-St. Paul and St. Louis, where they accounted for approximately two percent of total admissions.

The preferred method of taking methamphetamine varies among geographical regions.
Note: Calendar year in Hawaii and San Diego; State fiscal year in San Francisco.
Source: Community Epidemiology Work Group, NIDA 1997

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How is methamphetamine used?

Methamphetamine comes in many forms and can be smoked, snorted, orally ingested, or injected. The drug alters moods in different ways, depending on how it is taken.

Immediately after smoking the drug or injecting it intravenously, the user experiences an intense rush or “flash” that lasts only a few minutes and is described as extremely pleasurable. Snorting or oral ingestion produces euphoria – a high but not an intense rush. Snorting produces effects within 3 to 5 minutes, and oral ingestion produces effects within 15 to 20 minutes.

As with similar stimulants, methamphetamine most often is used in a “binge and crash” pattern. Because tolerance for methamphetamine occurs within minutes – meaning that the pleasurable effects disappear even before the drug concentration in the blood falls significantly – users try to maintain the high by binging on the drug.

In the 1980’s, “ice,” a smokable form of methamphetamine, came into use. Ice is a large, usually clear crystal of high purity that is smoked in a glass pipe like crack cocaine. The smoke is odorless, leaves a residue that can be resmoked, and produces effects that may continue for 12 hours or more.

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Amphetamine is a central nervous system stimulant that is used in the treatment of attention deficit hyperactivity disorder, narcolepsy, and obesity. Amphetamine was discovered in 1887 and exists as two enantiomers: levoamphetamine and dextroamphetamine.

Formula: C9H13N
IUPAC ID: 1-phenylpropan-2-amine
Duration of action: IR dosing: 3–6 hours; XR dosing: 8–12 hours
Onset of actionIR dosing: 30–60 minutes; XR dosing: 1.5–2 hours
MetabolismCYP2D6, DBH, FMO3
Elimination half-life: D-amph: 9–11 hours; L-amph: 11–14 hours; pH-dependent: 7–34 hours
ChiralityRacemic mixture

How is methamphetamine different from other stimulants, like cocaine?

How is methamphetamine different from other stimulants, like cocaine?

Methamphetamine is classified as a psychostimulant as are such other drugs of abuse as amphetamine and cocaine. We know that methamphetamine is structurally similar to amphetamine and the neurotransmitter dopamine, but it is quite different from cocaine. Although these stimulants have similar behavioral and physiological effects, there are some major differences in the basic mechanisms of how they work at the level of the nerve cell. However, the bottom line is that methamphetamine, like cocaine, results in an accumulation of the neurotransmitter dopamine, and this excessive dopamine concentration appears to produce the stimulation and feelings of euphoria experienced by the user. In contrast to cocaine, which is quickly removed and almost completely metabolized in the body, methamphetamine has a much longer duration of action and a larger percentage of the drug remains unchanged in the body. This results in methamphetamine being present in the brain longer, which ultimately leads to prolonged stimulant effects.

Although both methamphetamine and cocaine are psychostimulants, there are differences between them.

METHAMPHETAMINE COCAINE
Smoking produces a high that lasts 8-24 hours Smoking produces a high that lasts 20-30 minutes
50% of the drug is removed from the body in 12 hours 50% of the drug is removed from the body in 1 hour
Limited medical use Used as a local anesthetic in some surgical procedures

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Uses of Amphetamine Tablets:

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The combination of dextroamphetamine and amphetamine is in a class of medications called central nervous system stimulants. It is used as part of a treatment program for attention deficit hyperactivity disorder (ADHD). … 91 patient evaluations for Amphetamine-Dextroamphetamine.

What are the Medical Complications of Methamphetamine Use?

What are the Medical Complications of Methamphetamine Use?

Methamphetamine can cause a variety of cardiovascular problems. These include rapid heart rate, irregular heartbeat, increased blood pressure, and irreversible, stroke-producing damage to small blood vessels in the brain. Hyperthermia (elevated body temperature) and convulsions occur with methamphetamine overdoses, and if not treated immediately, can result in death.

Chronic methamphetamine abuse can result in inflammation of the heart lining, and among users who inject the drug, damaged blood vessels and skin abscesses. Methamphetamine abusers also can have episodes of violent behavior, paranoia, anxiety, confusion, and insomnia. Heavy users also show progressive social and occupational deterioration. Psychotic symptoms can sometimes persist for months or years after use has ceased.

Acute lead poisoning is another potential risk for methamphetamine abusers. A common method of illegal methamphetamine production uses lead acetate as a reagent. Production errors may therefore result in methamphetamine contaminated with lead. There have been documented cases of acute lead poisoning in intravenous methamphetamine abusers.

Fetal exposure to methamphetamine also is a significant problem in the United States. At present, research indicates that methamphetamine abuse during pregnancy may result in prenatal complications, increased rates of premature delivery, and altered neonatal behavioral patterns, such as abnormal reflexes and extreme irritability. Methamphetamine abuse during pregnancy may be linked also to congenital deformities.

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amphetamine salt combo (Adderall) is a moderately priced drug used to treat attention-deficit hyperactivity disorder (ADHD) and narcolepsy (uncontrollable desire for sleep or sudden attacks of deep sleep).

Dextroamphetamine Listen to pronunciation
Common brands: Dexedrine Spansule, Zenzedi, ProCentra

What are the Immediate (Short-Term) Effects of Methamphetamine Use?

What are the Immediate (Short-Term) Effects of Methamphetamine Use?

As a powerful stimulant, methamphetamine, even in small doses, can increase wakefulness and physical activity and decrease appetite. A brief, intense sensation, or rush, is reported by those who smoke or inject methamphetamine. Oral ingestion or snorting produces a long-lasting high instead of a rush, which reportedly can continue for as long as half a day. Both the rush and the high are believed to result from the release of very high levels of the neurotransmitter dopamine into areas of the brain that regulate feelings of pleasure.

Short-term effects of methamphetamine abuse:

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  • Euphoria and rush
  • Increased respiration
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Methamphetamine has toxic effects. In animals, a single high dose of the drug has been shown to damage nerve terminals in the dopamine-containing regions of the brain. The large release of dopamine produced by methamphetamine is thought to contribute to the drug’s toxic effects on nerve terminals in the brain. High doses can elevate body temperature to dangerous, sometimes lethal, levels, as well as cause convulsions.

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